Disputas- Master i biovitenskap Anne Kristin McLaren Berge

Avhandlingen er tilgjengelig her! The doctoral thesis! Prøveforelesningen starter kl. 0915 samme sted, og har følgende tittel: E3 ubiquitin ligases as targets in cancer therapy: Current status and future perspectives. Prøveforelesningen strømmes her/ the trail lecture will be streamed here. Disputasen starter 11.15 og kan strømmes her. Auditoriet er åpent for publikum, men disputasen vil også bli strømmet. Opptak av disputasen vil være tilgjengelig i et døgn. The auditorium is open to the public. The defense will still be streamed here. Recordings of the trial lecture and the defense will be available for 24 hours.

Populærvitenskapelig sammendrag:

Cancer is a disease, defined by uncontrollably cell growth and can potentially spread to other parts of the body. The cancer cells, or the body’s reaction to cancer, can send out messages that can help us understand the behavior of the cancer. Therefore, research today is actively trying to find these messages and figure out how to use them to improve cancer treatment. These messages include modifying TRIM proteins, that can tag other proteins for destruction or influence their function.
Using computational methods and lab experiments, we have identified that these modifying
proteins have an impact on the survival of cancer patients. These proteins can also take a part in the clean-up of mitochondria, often called the powerhouse of the cell, which can have an effect on cancer. Understanding the role of these modifying proteins in cancer can lead to the development of new treatments, enhancing patient survival and overall well-being.

Hovedveileder
Førsteamanuensis Erik Knutsen, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.
 

Bedømmelseskomité
Førsteamanuensis Johan Staaf, Lund University Cancer Centre – 1. Opponent.
Seniorforsker, ph.d. Edward Leithe, Oslo Universitetssykehus – 2. opponent.
Professor Kristin Andreassen Fenton, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT– leder av komité.

Disputasleder: Instituttleder Eva Sjøttem, Institutt for medisinsk biologi, UiT Norges arktiske universitet