Bilde av Heiland, Ines
Photo: Art of moments
Bilde av Heiland, Ines
Department of Arctic and Marine Biology ines.heiland@uit.no +4777646889 Tromsø You can find me here

Ines Heiland


Job description

Prof. for Molecular Biology and Bioinformatics


  • Yin-Chen, Mathias, Ines :
    ProTaxoVis—protein taxonomic visualisation of presence
    BMC Bioinformatics 2025 DOI
  • Suraj, Roland, Madlen, Aaron Marcellus Paul, Marc, Tobias et al.:
    GEMCAT - a new algorithm for gene expression-based prediction of metabolic alterations
    NAR Genomics and Bioinformatics 2025 DOI
  • Roland, Suraj, Ines :
    Accounting for NAD Concentrations in Genome-Scale Metabolic Models Captures Important Metabolic Alterations in NAD-Depleted Systems
    Biomolecules 2024 DOI / ARKIV
  • Lena Elise, Magali R Van, Marc, Øyvind, Suraj, Jörn Lukas Franz et al.:
    Subcellular NAD+ pools are interconnected and buffered by mitochondrial NAD+
    Nature Metabolism 2024 DOI / ARKIV
  • Anna-Sophia, Eva, Suraj, Tobias, Madlen, Thomas et al.:
    Linking metabolism and histone acetylation dynamics by integrated metabolic flux analysis of Acetyl-CoA and histone acetylation sites
    Molecular Metabolism 2024 DOI / ARKIV
  • Suraj, Yin-Chen, Jørn, Mathias, Øyvind, Mathias et al.:
    Early Evolutionary Selection of NAD Biosynthesis Pathway in Bacteria
    Metabolites 2022 DOI / ARKIV
  • Jørn, Alienke van, Anna-Sophia, Mathias, Marcel, Ines :
    Natural isotope correction improves analysis of protein modification dynamics
    Analytical and Bioanalytical Chemistry 2021 DOI
  • Mathias, Magnus, Andrey, Gennaro, Ines, Ferdinando :
    Welcome to the Family: Identification of the NAD+ Transporter of Animal Mitochondria as Member of the Solute Carrier Family SLC25
    Biomolecules 2021 DOI / ARKIV
  • Verena, Saša, Ahmed, Dennis, Tobias, Saskia et al.:
    Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma
    Theranostics 2021 DOI / ARKIV
  • Soumya R, Ahmed, Suraj, Gernot, Hagen M, Tobias V et al.:
    Hypoxia Routes Tryptophan Homeostasis Towards Increased Tryptamine Production
    Frontiers in Immunology 2021 DOI / ARKIV / FULLTEKST
  • Mirja Tamara, Ulrike, Marti Cadena, Ann-Sofie De, Ralf, Laura et al.:
    G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
    Cell 2021 DOI / ARKIV / SAMMENDRAG / OMTALE
  • Alienke Van, Jørn, Alejandro Sánchez, Anna-Sophia, Tim, Andrei et al.:
    Combined metabolic and chemical (CoMetChem) labeling using stable isotopes - A strategy to reveal site-specific histone acetylation and deacetylation rates by LC-MS
    Analytical Chemistry 2021 DOI
  • Fabrizio, Jingyi, Antal, Ines, Pia Abel zur :
    Multi-scale modeling of drug binding kinetics to predict drug efficacy
    Cellular and Molecular Life Sciences (CMLS) 2019 DOI / ARKIV
  • Soumya R., Ahmed, Lars-Oliver, Jørn, Gernot, Ines et al.:
    Hypoxia Inducible Factor 1α Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma
    Frontiers in Immunology 2019 DOI / ARKIV
  • Alexander Martin, Patricia Razquin, Miriam, Katharina, Ahmed, Erik et al.:
    The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner
    Life Science Alliance (LSA) 2019 DOI / ARKIV
  • Mathias, Dorothee, Marc, Toni I., Ines, Alexander et al.:
    Identification of evolutionary and kinetic drivers of NAD-dependent signaling
    Proceedings of the National Academy of Sciences of the United States of America (PNAS) 24. Juli 2019 DOI / ARKIV
  • Øyvind, Marc, Andrey, Magali R Van, Ines, Mathias :
    Keeping the balance in NAD metabolism
    Biochemical Society Transactions 2019 DOI / ARKIV
  • Mathias, Ines, Karsten :
    The evolution of the plastid phosphate translocator family
    Planta 2019 DOI
  • Arina, Mathias, Christopher, Ines, Toni Ingolf :
    Human long intrinsically disordered protein regions are frequent targets of positive selection
    Genome Research 2018 DOI / ARKIV
  • Isabell, Dyah L., Joram, Ahmed, Soumya R., Bianca et al.:
    Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation
    Oncoimmunology 2018 DOI / ARKIV
  • Sascha, Anne-Kristin, Mathias, Pål, Ines :
    SBMLmod: a Python-based web application and web service for efficient data integration and model simulation
    BMC Bioinformatics 2017 DOI / ARKIV
  • Dyah L, Soumya R, Saioa Blanco, Isabell, Luis F Somarribas, Bianca et al.:
    Suppression of indoleamine-2, 3-dioxygenase 1 expression by promoter hypermethylation in ER-positive breast cancer
    Oncoimmunology 2017 DOI
  • Christiane A., Ines :
    Dynamics of NAD-metabolism: everything but constant
    Biochemical Society Transactions 2015 DOI
  • Ines, K :
    Nutrigenomics: Toward a cross-disciplinary understanding of nutrient-driven networks in health and disease: What can we learn from the study of cross-talk in complex protein kinase and metabolic networks?
    Aktuelle Ernãhrungsmedizin 2015 DOI
  • Ines :
    Chemo Informatik: Was hat Tryptophan mit Krebs und Parkinson zu tun?
    Chemie in unserer Zeit 2014 DOI
  • Walter, Bernd, Gaquerel, Ian T., Kim, Ines :
    Improving the accuracy of expression data analysis in time course experiments using resampling
    BMC Bioinformatics 2014 DOI / ARKIV / FULLTEKST
  • Kathrin, Johannes, Doreen, Sandra, Steffen, Ines et al.:
    Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide
    Nature Chemical Biology 2013 DOI
  • Anne-Kristin, Ines, Stefan, Pål, Mathias :
    Model of tryptophan metabolism, readily scalable using tissue-specific gene expression data
    Journal of Biological Chemistry 2013 DOI / ARKIV
  • Roland, Ines :
    Metabolites at Genome-Scale: Towards Genome-Scale Modeling Strategies for Metabolite Concentrations
    UiT Norges arktiske universitet 28. Oktober 2025
  • Sunniva Katharina, Ines :
    Energisentrene i cellene holder oss friske
    23. Februar 2025 FULLTEKST
  • Sunniva Katharina, Ines :
    NAD og aldring: Dette skjer i cellene når vi blir eldre
    09. März 2025 FULLTEKST
  • Ines :
    Kinetic regulation of NAD homeostasis
    2022
  • Anze, Hans Christopher, Ines :
    Systems biology – Current status and challenges
    Cellular and Molecular Biology 2020 DOI / ARKIV
  • Mathias, Ines, Toni Ingolf, Thomas :
    Sequence-Based Analysis of Eukaryotic Protein Evolution
    UiT Norges arktiske universitet 12. Oktober 2018
  • Toni Ingolf, Arina, Mathias, Ines, Cooney :
    Human intrinsically long disordered protein regions are frequent targets of positive selection
    2017
  • Roland, Ines :
    Arctic Marine Bioplastics
    2017
  • Roland, Ines :
    Metabolic Modeling of Marine Biomass Conversion
    2016
  • Ines, Mathias, Pål, Sascha, Anne-Kristin :
    Tissue specific models of Trp- and NAD-metabolism — insights into metabolic crosstalk.
    2016
  • Ines, Mathias, Anne-Kristin, Pål, Mathias :
    Tissue specific models of Tryptohan-metabolism — insights into metabolic crosstalk
    2016
  • Mathias, Ines, Gossmann, Mathias :
    Phylogenetic and simulation-based analysis of NAD metabolism
    2016
  • Mathias, Ines :
    Phylogenetic Analysis of NAD biosynthesis and consumption
    2016
  • Carolyn, Thomas, Ines :
    50 Years of FEBS´ Education Training Awards
    FEBS News 2015 FULLTEKST
  • Mathias, Anne-Kristin, Toni I., Mathias, Ines :
    Dynamics of NAD-metabolism - everything but constant
  • Mathias, Ines :
    Phylogenetic Analysis of NAD biosynthesis and consumption
    2015
  • Mathias, Ines :
    Use of resampling to improve accuracy of data analysis in time course experiments
    2015
  • Anne-Kristin, Ines, Stefan, Pål, Mathias :
    Predicting pathological metabolic changes using a kinetic model of tryptophan metabolism
    2014
  • Ines, Susanne, Anne-Kristin, Christian, Mathias :
    NAD-metabolism and the circadian clock -- Unraveling contradictions
    2014
  • Wencke, Emmanuel, Ian T., Sang-Gyu, Ines :
    Improving the analysis of high throughput time course data using modelling based approaches
    2014
  • Ines, Susanne, Anne-Kristin, Christian, Mathias :
    NAD-metabolism and the circadian clock
    2013
  • Ines :
    Metabolic modelling: From networks to dynamics and back
    2013

  • The 50 latest publications is shown on this page. See all publications in Cristin here →

    Research interests

    Mathematical simulations are an important tool in physics and engineering, but its application to biology and medicine is still in its infancy. However, as our knowledge of the molecular basis of biological processes is progressing, mathematical modelling is increasingly used to understand the complexity of living organisms.

    We use existing biochemical data to built dynamic models of metabolisms and ageing. The resulting models can be used to understand the basis of diseases and guide the development of drugs. We work in close collaboration with experimental groups, which is advantageous, as model building is always an iterative process of simulation and experimental verification of model hypothesis. It furthermore guides the developement of our models and usually defines the aim of the model.

    Teaching

    Current teaching activities

    BIO-2018 Anvendt molekylærbiologi og bioinformatikk 

    BIO-3027 Scientific Programming with Pyhthon for Life Sciences

    BIO-3010/8011 Modelling in Systems Biology I -Metabolic pathway modelling

    Chair of the board of the National Research School for Bioinformatics, Biostatistics and Systems Biology (NORBIS)

    Past teaching activities:

    Basis pedagogisk kompetanse 2016 - Pedagogisk mappe




    CV

    Positions

     

    Sept/2015 - Prof. for molecular biology and  bioinformatics at the Department of arctic and marine biology

     

    Dec/2012 - Sept/2015 Assoc. Prof. for molceular bioinformatics at the Department of arctic and marine biology

    2008 - 2012
    Postdoctoral researcher and junior group leader at the Friedrich Schiller University Jena, Department of Bioinformatics
    Project: Modelling and simulation of circadiane rhythms and dynamic metabolic processes

    2005 - 2006
    Postdoctoral reseracher at the FSU Jena Department of General Botany
    Project: Data evaluation of large scale proteome projects of C. reinhardtii

    2004 - 2005
    Postdoctoral researcher at the Ruhr University Bochum Laboratory of Systems Biochemistry
    Project: Characterisation of the Pex3p-Complexes of Saccharomyces cerevisiae

     

    PhD-Thesis

    2003 - 2004 Ruhr Universit Bochum, Laboratory of Systems Biochemistry
    2001 - 2002 Department of Biochemistry, Free University Berlin

    I have done my PhD-thesis in the group of Prof. Ralf Erdmann. The title of my work was: "Investigating peroxisomal membrane biogenesis". I have defended my PhD thesis at the 19th of November in 2004 at the FU Berlin.

     

    Internships

    04/2011 - 05/2011 Computational Biology Unit, Uni Reserach, Bergen, Norway

    03/2004 - 04/2004 Biological school of sciences, C. Stirling Group, Manchester University, England

    06/1999 - 07/1999 Department of Organic Chemistry, S. Oscarsons Group, Arhenius Laboratories, Stockholm University, Sweden

     

    Undergraduate Studies in Biochemistry

    1995 - 1997 Friedrich Schiller University Jena
    1997 - 2000
    Free University Berlin

    Biologibygget 2.052


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