Bacterial infection biology: Virulence and pathogenesis

HMI is using several approaches to study colonization, virulence and pathogenesis of S. aureus, K. pneumoniae and E. faecium. We have a large collection of nasal- and throat-isolates of S. aureus obtained from adults and adolescents of the Tromsø-population and use comparative genomics to find determinants involved in S. aureus colonization (PI Johanna). We also have a large collection of E. faecium both from clinical samples and from adults of the Tromsø-population as well as their genome sequences for which we apply machine learning to identify relevant target genes more prevalent in clinical E. faecium isolates ( PI Kristin). We use chemical probes to visualize, detect, and identify enzymatic activities of clinical/commensal bacterial strains during infection and colonization (PI Christian).  The various determinants/enzymes are further analyzed with respect to their adhesive, invasive and immune evasive properties (PI Mona, PI Christian, PI Johanna, PI Anne-M, PI Kristin)

CURRENT PROJECTS

Identification of key determinants for Staphylococcus aureus throat colonization: a transcriptomic approach

2020-2024           

Funding: UiT – The Arctic University of Norway (PhD position). Consumables: The Odd Berg Group Medical Research Fund, Northern Norway Regional Health Authority Medical Research Programme projects number HNF 1597-21 and HNF 1475-19. 

Main objective: Assess host-microbe interaction and present lead candidates for targeted intervention of S. aureus throat colonization and thereby prevent infection. Secondary objectives:

• Establish an in vitro tonsillar model system for studying S. aureus colonization
• Assess the S. aureus transcriptome in throat colonization under in vitro and in vivo conditions
• Determine transcriptomic profiling of S. aureus during in vitro co-culture with interacting throat bacteria.

Team: Anne Merethe Hanssen, Srijana Bastakoti, Mona Johannessen, Clement Ajayi, Kjersti Julin 

Papers: Co-culturing with Streptococcus anginosus alters Staphylococcus aureus transcriptome when exposed to tonsillar cells; Exploring differentially expressed genes of Staphylococcus aureus exposed to human tonsillar cells using RNA sequencing

Activity-based protein profiling of multi-drug resistant pathogens

2021-2024            

Funding: Northern Norway Regional Health Authority HNF1570-21, CANS-start up fund

Objectives: Identification of enzymatic activities of Enterococcus faecium, Staphylococcus aureus and Klebsiella pneumoniae, their evaluation of their role in virulence and infection and as putative drug targets.

Team: Christian Lentz (Team Leader), Jeanette Grunnvåg, Md Jalal Uddin, Kristin Hegstad, Mona Johannessen

Dissecting the phenotypic heterogeneity of isogenic bacterial pathogen populations related to infection and antimicrobial resistance

since 2021           

Funding: CANS-startup funds and NFR (#319829)

Objectives

• To detect and manipulate cellular subpopulation phenotypes and understand cooperative behavior in cellular bacterial pathogen populations during infection. 
• To develop and apply chemical probes for cellular phenotypic profiling of dynamic traits of bacteria and as putative biomarkers.

Team: Christian Lentz (Team leader), Jonathan Hira, Roni Miah, Nadia Aftab, Bhupender Singh, Balqees Olobada, Jasmin Wilhelmsen, Sonja Niederl, Mona Johannessen, Kristin Hegstad

Human microbiome: Homeostasis and modulation

Our group has several projects studying the gut microbiome of both adults and children. In adults, we are investigating the Klebsiella pneumoniae gut colonization pattern and ecology, recruiting persons from the Tromsø study with access to extensive metadata (PI Arnfinn). We collaborate with the Pediatric Research group on projects investigating how the microbiome mediates colonization resistance against pathogens, how it is linked to cancer development, and how it is formed in infancy (PI Veronika). 

CURRENT PROJECTS

Gut Microbiome-based Biomarkers to Prevent Infections by Antimicrobial Resistant Bacteria in Infancy

2021 - 2026            

Funding: Northern Norway Regional Health Authority HNF1584-21, Tromsø Research Foundation via the Centre for New Antibacterial Strategies (18_CANS_AS), The Odd Berg Group Medical Fund

This research project leverages two cohort studies of term infants to describe the impact of antibiotics and probiotics on their gut microbiome. The first is a randomized clinical trial co-led by the Paediatric Research group in Tromsø (UiT/UNN), which investigates the effects of probiotic therapy in Tanzanian children and its potential to prevent infections by ESBL-producing Enterobacterales (ProRIDE: Probiotics to Reduce Infections and Death and Prevent Colonization with ESBL- producing bacteria). The second study is a prospective, observational pilot study of infants with suspected symptoms of infection during the 1st week of life leading to antibiotic therapy (IMPALE: Impact of Antibiotics on the Neonatal Metabolome).

The aim of both studies is to describe changes in faecal metabolites and microbial composition in association with antibiotic/probiotic use, drug-resistant strain colonization, and a risk of infection.

Team: Veronika K Pettersen, Ahmed Bargheet, Gaute H. Bø, Claus klingenberg, Synnøve Holmebukt, Oda Marie Aspenes Gundersen, Julia Maria Kloos, Wasifa Kabir, Hermoine Jean Venter

Compositional and metabolic changes of the gut microbiome in childhood cancers

2021 - 2025             

Funding: Barnekreftforeningen, Erna & Olav Aakres Foundation, Tromsø Research Foundation via the Centre for New Antibacterial Strategies (18_CANS_AS)

The project is a collaboration between the Paediatric Research group at UiT, Norwegian Childhood Cancer Biobank, and researchers from the Centre for Ecological and Evolutionary Synthesis at the University of Oslo. In this project, we explore the compositional variation of the gut microbiome in paediatric cancer patients. By using DNA sequencing methods and metabolite profiling, we are characterizing features of the gut microbiome associated with cancer diagnoses in children. The goal is to describe microbiome-based markers that discriminate cancer cases from healthy controls and microbial metabolites that can serve as diagnostic biomarkers in therapeutic explorations.

Team: Veronika K Pettersen, Trond Flægstad, Anne Asla Bentzen, Hildegunn N Granslo, Ole Martin Nilsen, Julia Maria Kloos

Antimicrobial resistance: Mechanisms, drivers and evolution

As partner in the cross-faculty “DigiBiotics” project we contribute with MIC- and mode of action assays to the antimicrobial drug discovery pipeline designed for new antimicrobial hits development (PI Johanna). We study the heterogeneity and dynamics of antimicrobial resistance within bacterial pathogen populations in subpopulations and single cells (PI Christian); as well as structural analysis to explore enzyme adaptation/evolution in AMR (PI Christopher Frøhlich)(LacZymes). In collaboration with the National reference centre for detection of antimicrobial resistance (K-res) we are performing molecular characterization and extended antimicrobial susceptibly testing of WHO-prioritized multi-drug resistant Gram-negative pathogens (PI Arnfinn) and enterococci (PI Kristin).

CURRENT PROJECTS

Closing the diagnostic gap in adaptive antimicrobial resistance of multi-drug resistant Gram-negative pathogens 

2023 – 2026        

Funding: Northern Norway Regional Health Authority Medical Research Programme project number HNF 1570-21  

The primary objective of this work is to quality control and improve in vivo relevance of current cefiderocol antimicrobial susceptibility testing. The project pursues the following objectives:

• Evaluate the scope and clinical relevance of the adaptation gap in antimicrobial susceptibility testing of multi-drug resistant Escherichia coli and Klebsiella pneumoniae.
• Assess antimicrobial susceptibility parameters directly in clinical samples.
• Evaluate the relevance of cellular phenotypic heterogeneity in antimicrobial susceptibility.

Project and work package leader: Christian Lentz (HMI, UiT), Co-project leader: Arnfinn Sundsfjord (HMI, UiT/K-Res), Work package leader: Einar Holsbø (Institute for Informatics, UiT), Project team members: Jonathan Hira (HMI, UiT), Knut Rustad (HMI, UiT), Julia Kloos (HMI, UiT), Ørjan Samuelsen (UNN/UiT). Collaborators: Mark Broenstrup, Dept, of Chemical Biology, Helmhotz-Centre for Infection Research, Braunschweig, Germany; Kimberly Beatty (OHSU, Portland, US); Marius Haugland (Chemistry,

Persistence and spread of resistance determinants in enterococci

2014-2025

Funding: UiT – The Arctic University of Norway (2-year PhD grant for Medical Research student), Northern Norway Regional Health Authority Medical Research Programme (HNF1362-17) and Norwegian National Advisory Unit on Detection of Antimicrobial Resistance (K-res)

Aim/objective(s): Increase understanding of 1) successful clones and mobile genetic elements contributing to the spread of resistance in enterococci and 2) novel mechanisms of resistance

Team: Kristin Hegstad (K-res UNN/HMI UiT), Arnfinn Sundsfjord (HMI UiT/K-res UNN), Theresa Wagner (HMI UiT), Audun Sivertsen (HMI UiT), Jessin Janice (K-res UNN/HMI UiT), Mushtaq AL-Rubaye (HMI UiT), Torunn Pedersen (K-res UNN); and national and international collaborators

The project has so far resulted in 19 research publications, among them three reviews: DOI:10.1371/journal.pone.0103274; DOI:10.1128/AAC.00286-16; DOI:10.1128/mSphere.00402-18; DOI:10.1093/jac/dkaa541; DOI:10.1093/jac/dkad024 (review) ; DOI:10.1016/j.ijantimicag.2023.106849; DOI:10.1371/journal.pone.0255187; DOI:10.1111/apm.12100; DOI:10.3109/00365548.2014.923107; DOI:10.1186/s12864-015-1407-6; DOI:10.1093/jac/dkw312 (review); DOI:10.1016/j.drup.2018.10.002 (review); DOI:10.1371/journal.pone.0211741; DOI:10.1186/s13073-021-00868-0; DOI:10.1016/S2666-5247(21)00236-6; DOI:10.1038/s41467-022-29274-9; Doi: 10.1099/mgen.0.001154; Doi: 10.1016/j.cmi.2023.12.002; Doi:10.1099/mgen.0.001160.

Klebsiella pneumoniae – a key driver in the global spread of antimicrobial resistance and a target for new approaches in diagnostics, surveillance and alternative therapeutics (KLEB-GAP)

2019-2024

Funding: Trond Mohn Research Foundation, Northern Norway Regional Health Authority Medical Research Programme project number HNF 1589-21
Objectives:

1. Determine the presence, population structure, and pan-genome of K. pneumoniae in human, animal, and marine reservoirs to elucidate potential eco-adaptation and crosstalk between reservoirs.
2. Explore whole metagenomic sequencing for detection and in-depth analysis of K. pneumoniae population genomics in selected reservoirs.
3. Identify new pathogenicity loci, and predict antimicrobial resistance and virulence phenotypes from whole genome sequence data
4. Pre-clinical evaluation of lytic bacteriophages as antimicrobials against multidrug resistant K. pneumoniae.

Project team: Arnfinn Sundsfjord (UiT – PI) , Iren Löhr (Stavanger University Hospital), Ørjan Samuelsen(Gunnar Skov Simonsen (University Hospital of North Norway), Marianne Sunde (Norwegian Veterinary Institute), Bjørn Tore Lunestad (Institute for Marine Research), Cyril Frantzen (ACD Pharma), Christian Giske (Karolinska Institute-Stockholm), Sylvain Brisse (Pasteur Institute – Paris), Jose Bengochea (Queens University – Belfast) and Kathryn Holt (Monash University, Melbourne, and London School of Hygiene and Tropical Medicine, London)

The project has so far led to 13 research publications: https://doi.org/10.3390/microorganisms8121909; https://doi.org/10.1101/2021.07.16.452602; https://doi: 10.1080/19490976.2021.1939599; https://doi.org/10.3389/fmicb.2021.725414; https://doi.org/10.1093%2Fjac%2Fdkab463; https://doi.org/10.1016/j.ijheh.2022.113967; https://doi.org/10.1080/19490976.2022.2118500; https://doi.org/10.1099/mgen.0.000960; https://www.frontiersin.org/articles/10.3389/fmicb.2023.1193274/full; https://doi.org/10.1099/mgen.0.001005; https://doi.org/10.1128/msphere.00025-23; https://doi.org/10.1093/molbev/msac135; https://doi.org/10.1002/mbo3.1368

Past Projects

Digital discovery of antimicrobial molecules from marine Artic resources with reduced risk of triggering resistance

2017-2023

Funding: Research Council of Norway (RCN) project number 269425 and UiT the Arctic University of Norway cross-faculty strategic funding AntiBioSpec

The goal of DigiBiotics is to translate innovative scientific discoveries into commercially attractive propositions by combining in-depth scientific knowledge with a broad understanding of the requirements of successful drug discovery and development. This goal will be reached by fulfilling five scientific objectives and one training objective:
• Digitally mine genomes, isolate and identify novel antimicrobial molecules from Arctic marinemicroorganisms with a selection of compounds less prone to trigger resistance development
• Create, develop and validate experimental and computational methods for determination of molecular
structure, absolute configuration and conformation.
• Provide, through new computational and experimental methods, an in-depth understanding of structure activity
relationships for "middle-space molecules" enabling optimization of their biological activity
• Compute quantitative structure activity relationships (QSAR) for knowledge-driven refinement of antimicrobial molecules into compounds with acceptable pharmacokinetics, optimizing potency,absorption, distribution and metabolic properties.
• Define the microbial targets and resistance development to provide feedback for refined design.
• Train young scientists in the cross-disciplinary skills needed for future successful drug discovery

Project team: John Sigurd Svendsen (IK), Bjørn Olav Brandsdal (IK), Kenneth Ruud (IK), Johan Isaksson (IFA), Jeanette Hammer Andersen (NFH), Johanna U Ericson (IMB)
The project has so far led to two research publications: https://doi.org/10.3390/md20050277; https://doi.org/10.3390/biom13071155

Membrane Vesicles (MVs): characterization and possibilities as vaccine and use as vehicle in vitro

2017-2023

Funding: UiT-funded PhD position; Northern Norway Regional Health Authority Medical Research Programme funded post doctoral fellow, The National Health Register for Monitoring of Antibiotic Resistance 2020 (NORM); CANS-funded PhD position.
The main objective is to identify the cargo of membrane vesicles from the Gram-positive bacteria staphylococci and E. faecium, and to address whether environmental factors influence it. We also aim to evaluate whether bacterial MVs can be used as vaccine, and whether they can be used as in vitro models for studying interaction with- and permeability with bacterial membranes.
Project team: Kristin Hegstad (K-res UNN/HMI UiT), Mona Johannessen (HMI UiT) Bishnu Joshi (HMI UiT) Theresa Maria Wagner (HMI UiT), Fatemeh Askarian (HMI UiT), Bhupender Singh, Jessin Janice, Ole Hagestad, Ahmed Mekhlif, Pauline Cavanagh (IKM UiT), Gøril Eide Flaten (IFA UiT), Johan Isaksson (IFA UiT) Johanna U. Ericson (HMI UiT) and international collaborators
The project led to 7 research publications: DOI: 10.3389/fmicb.2018.00262; https://doi.org/10.1016/j.jprot.2018.05.017; DOI: 10.1016/j.jprot.2018.11.013; DOI: 10.1016/j.dib.2018.11.147;  DOI: 10.3389/fmolb.2020.566207; doi: 10.3390/microorganisms9102055; https://doi.org/10.3390/ijms242216051

A metagenomics approach for laboratory diagnostics in clinical microbiology

2016-2020

Funding: UiT – the Arctic University of Norway. Grant: UiT funded PhD position, and “Likestillingsmidler”; also supported by “Miljøstøtte” financed by Strategisk-HN05–14 (Helse Nord RFH) and Faculty of Health Sciences A20389, and the National Graduate School in Infection Biology and Antimicrobials (grant number 249062).
Objectives: The main objective was to explore the use of shotgun-metagenomics (SMg) in clinical diagnostics of prosthetic joint infection (PJI) for the identification of potential pathogens and prediction of antimicrobial resistance (AMR) and virulence determinants directly from blood culture bottles (BCBs) inoculated with periprosthetic tissue (PJT) specimens.
Project team: Anne Merethe Hanssen; Adriana Sanabria, Johanna Ericson, Mona Johannessen, Gunnar Skov Simonsen
The project led to three research publications. The diagnostic method was taken in use at the routine laboratory at department for microbiology and infection control at UNN for diagnosis of PJI. https://doi.org/10.1038/s41598-021-00383-7; https://doi.org/10.3389/fmicb.2020.01687; https://doi.org/10.1186/s12879-019-4206-x

Consortium positioning for Centre for Infection Prevention and Treatment (preCIPT)

2014- 2017

Funding: Miljøstøtte from Faculty of Health Sciences at UiT the Arctic University of Norway and Northern Norway Regional Health Authority Medical Research Programme
Project team: Johanna Ericson, Mona Johannessen, Anne-Merethe Hanssen, Kristin Hegstad (HMI/K-res), Arnfinn Sundsfjord (HMI/K-res), Gunnar Skov Simonsen (HMI/UNN), Torunn Pedersen (K-res), Ørjan Samuelsen (K-res), Trond Flægstad (IKM), Claus Klingenberg (IKM), Kaare M.Nielsen (IFA), Pål J. Johnsen (IFA), Nils P. Willassen, Erik Hjerde (IK), Hanna Kirsti S. Leiros (IK) and Morten Strøm (IFA).
The outcome of preCIPT was increased collaboration between researchers across borders of faculty and departments. The project paved the way additional collaborations and the establishment of CANS | UiT.

Molecular aspects of host-microbe interaction

2011-2018

The main objectives are to identify bacterial determinants important for colonization and/or infection, and explore therapeutic potential of novel bacterial molecules.
Funding: UiT- PhD position, HN (SFP1157-14), HN (FP-1231-159), preCIPT
Project team: Mona Johannessen (HMI UiT), Kristin Hegstad (HMI UiT/K-res UNN), Fatemeh Askarian (HMI UiT), Theresa Wagner (HMI UiT), Johanna Ericson (HMI UiT), Anne-Merethe Hanssen (HMI UiT), Clement Ajayi (HMI UiT), Maria Sangvik (HMI UiT), Ingvild Pettersen (HMI UiT), Torunn Pedersen (K-res UNN), Jørn Henriksen (HMI UiT), Tom Eirik Mollnes (UNN) and international collaborators

The project resulted in 6 research publications and 3 reviews: doi:10.3389/fcimb.2012.00056; DOI:10.1099/mic.0.069369-0; DOI:10.1111/2049-632X.12099; DOI:10.1159/000357618; DOI:10.1038/srep22134; DOI:10.1128/IAI.00559-16; DOI:10.1093/femsre/fuy025; DOI:10.1186/s12866-018-1179-7; DOI:10.1155/2018/1435820

Identification of host and microbe determinants for Staphylococcus aureus colonisation of healthy individuals ‐ targets for intervention

2009-2013

Funding: Research Council of Norway (RCN) project number 191264/V50, Northern Norway Regional Health Authority Medical Research Programme (Helse Nord RHF), grants Toppforskning [2004-09] and SFP877-09, and Miljøstøtte MIL963-10 [2010-2012]

Project team members: Johanna Sollid, Anne-Merethe Hanssen, Mona Johannessen, Gunnar Skov Simonsen, Maria Sangvik, Renate Slind Olsen, Fatemeh Askarian

The project resulted in 4 research publications and 1 review: https://doi.org/10.1128/jcm.05290-11, doi:10.3389/fcimb.2012.00056, DOI:10.1111/2049-632X.12017, https://doi.org/10.1111/2049-632x.12099, DOI:10.1186/s12866-017-0997-3

Mona Johannessen  –  Professor

Gunnar Skov Simonsen  –  Professor

Johanna U Ericson  –  Professor

Christopher Frøhlich  –  Associate Professor

Anne-Merethe Hanssen  –  Professor

Kristin Hegstad  –  Professor

Veronika K. Pettersen  –  Associate Professor

Arnfinn Sundsfjord  –  Professor

Kontaktperson for AMR Bridge, og ansvarlig for prosjektet ledet fra Tromsø.

Mona Johannessen  –  Professor

Christian Lentz  –  Professor

Seyed Mohammad Lellahi  –  Researcher

Øyvind Myrvoll Lorentzen  –  Researcher

Hermano Zenaide Neto  –  Postdoctoral Fellow

Rebekka Rolfsnes Hovd  –  Postdoctoral Fellow

Gaute Hovde Bø  –  Postdoctoral Fellow

Merethe E.O. Røkeberg

Marita Helen Augustinussen

Nadia Aftab  –  Doctoral Research Fellow

Anique Johanna Elisabeth Maria Driessen  –  Doctoral Research Fellow

Hege Sjåvik

Felix Schwab  –  Doctoral Research Fellow

Ole Martin Nilsen  –  Research Associate

Fatema-Tuz-Zahura Silvia  –  Research Assistant

Julia Maria Kloos  –  Head Engineer

Kjersti Julin  –  Senior Engineer

Bhupender Singh  –  Senior Engineer

Past PhD Projects

2026 Gaute Hovde Bø - The impact of probiotic and antibiotic use on the early life gut microbiome: A metabolomic approach.

2025 Ahmed Bargheet - The impact of probiotic and antibiotic use on the early life gut microbiota, resistome, and mobilome

2025 Jeanette Slettnes Grunnvåg - Identification and functional characterization of enzymes from Enterococcus faecium 

2024 Kenneth Lindstedt - Human gut colonisation by the Klebsiella pneumoniae Species Complex: improving detection and understanding of the presence, duration, dynamics, and microbiome associations
2024 Srijana Bastakoti - Identification of key determinants for Staphylococcus aureus throat colonization: A transcriptomic approach
2024 Md Jalal Uddin - Identification and validation of new enzymatic activities in pathogenic bacteria by activity-based protein profiling
2023 Mushtaq T. S. AL-Rubaye Exploring the genomes of the Norwegian vancomycin-resistant enterococci
2022 Eric Juskewitz Antimicrobial activity and mode of action: Examples from natural products, peptides, and peptidomimetics
2022 Faheema Choonara (University of KwaZulu-Natal) - Prevalence, Phenotypic and Genotypic Characterization of Resistant Clinical ESKAPE and Escherichia coli Isolates, at Kamuzu Central, Hospital, Lilongwe Malawi
2021 Bishnu Joshi Bacterial Extracellular vesicles and their cargo
2020 Adriana Maria Sanabria Moreno A Shotgun-metagenomics approach for laboratory diagnostics in clinical microbiology
2020 Ilya Nikolaevich Zykov Old antibiotics as alternative treatment options for urinary tract infections caused by ESBL-, AmpC- and carbapenemase-producing Escherichia coli
2018 Theresa Wagner How to Be a Bad Bug: Virulence Determinants of Enterococcus faecium
2018 Clement Olufemi Ajayi Determinants of Staphylococcus aureus Colonization and Infection
2017 Audun Sivertsen Mobile genetic elements causing plasticity in E. faecium
2016 Dagfinn Skaare Non-beta-lactamase-mediated beta-lactam resistance in Haemophilus influenzae
2015 Ståle Tofteland Extended-spectrum β-lactamases and carbapenemases in clinical isolates of Enterobacteriaceae in Norway.
2014 Biswa Nath Sharma Investigation of the antiviral effects of artesunate on BK and JC polyomavirus replication
2014 Fatemeh Askarian Molecular determinants involved during Staphylococcus aureus colonization and/or infection
2014 Iren Löhr Extended-spectrum β-lactamase (ESBL) producing Klebsiella pneumoniae: An outbreak in a neonatal intensive care unit, duration of colonization in children, intra-household transmission and ESBL-plasmid properties
2014 Ståle Tofteland Resistance to extended-spectrum cephalosporins in Escherichia coli and Klebsiella spp. in Norway. Prevalence, mechanisms, and molecular epidemiology.
2013 Jorunn Pauline Cavanagh The coagulase-negative staphylococci; molecular studies on Staphylococcus haemolyticus and novel treatment of staphylococcal biofilms in vitro and in vivo
2013 Karina Olsen  Staphylococcus aureus nasal carriage – Interplay between host, microbe and the environment
2013 Maria Sangvik Staphylococcus aureus colonisation and host-microbe interactions
2012 Stig Ove Hjelmevoll Molecular diagnostics and characterization of Neisseria gonorrhoeae
2012 Naga Pardha Saradhi Borra  Structural and biochemical investigation of Metallo-β-lactamases; Insights into the antibiotic binding sites
2012 Torill C. Solvær Rosvoll Plasmids, Resistance and Hospital adaptation in Enterococci -an epidemiological approach
2012 Torill Rosvoll Resistance and hospital adaptation in enterococci - an epidemiological approach
2012 Pardha Borra Structural and biochemical investigation of metallobetalactamases: insights into the antibiotic binding sites

Past MSc Projects

2026 Nazreit Eremias Mebrahtu - Profiling fecal metabolome changes associated with Klebsiella pneumoniae gut suppression following a low-FODMAP diet

2026 Sara K Fenton - Linking the Fecal Metabolome to Changes in Klebsiella pneumoniae Gut Colonization Following Fecal Microbiota Transplantation

2026 Shahid Zaheer - Characterization of Bacterial Subpopulation Growth Phenotypes in Antibiotic-Resistant Priority Pathogens

2025 Vera Brekken - Comparison of fecal short-chain fatty acid profiles between pediatric cancer patients and healthy controls

2025 Ida Svenningsen - The dual relationship between Klebsiella pneumonia and short-chain fatty acids

2025 Anique J E M Driessen - The role of serine hydrolases in the susceptibility of Klebsiella pneumonie to antimicrobial peptides

2024 Efat Muhammad Arshad - Characterization of Bifidobacterium longum carbohydrate metabolism by mass spectrometry-based omics
2024 Thomas Lien - Absolute quantification of E. coli from stool samples using qPCR
2024 Helle Stenseth - Pilot study of untargeted metabolomics methods to evaluate fecal metabolome of infants receiving probiotics or placebo (ProRIDE trial)
2024 Mia Petrell Langaas - The gut resistome in a community-based adult population
2024 Jasmin Wilhelmsen - Characterising heterogeneity of Staphylococcus aureus Fibronectin binding protein
2024 Balqees Adeola Olobada - Probes for Klebsiella pneumoniae and possible interactions
2023 Carolin Kornelia Fenzel Characterization of competition between commensal A2 and clinical A1 strains of Enterococcus faecium 
2023 Wasifa Kabir Duration and dynamics of Klebsiella pneumoniae species complex gut carriage in a community-based adult population cohort
2023 Karoline Lerengen Isolation of drug-resistant Enterobacterales from faecal samples of healthy newborns and characterisation of Bifidobacterium-mediated inhibition of drug-resistant Escherichia coli
2023 Sonja Niederl Profiling of the distribution of specific surface molecules in Staphylococcus aureus cell populations
2023 Rolf Simon Härmä Effects of microbiota modifying treatments on the faecal metabolome of infants: A systematic review
2023 Anna Härmä A Pilot Study: Potential of the Probiotic Product LaBiNIC® to Inhibit Cancer Cells
2022 Sigrid Sandli Determination of Short Chain Fatty Acids in Meconium from Healthy Term Infants
2022 Jan N Mentzen Empirisk antibiotikabehandling av ukompliserte nedre urinveisinfeksjoner hos ikke-gravide fertile kvinner - En sammenlignede undersøkelser av nasjonale retningslinjer
2021 Ira Spahiu Determinants of Staphylococcus aureus colonization and infection: Characterization of interaction between serine-aspartate containing protein D and human Siglec11 and Siglec16
2021 Daniel Engi Characterization of competition between commensal and clinical strains of Enterococcus faecium
2021 Elin H. Sollid Bakteriofagterapi mot multiresistente Gram-negative bakterieinfeksjoner - Systematisk gjennomgang av publiserte kasusrapporter.
2021 Mia Winkler Characterization of Klebsiella pneumoniae isolates by predicted serotype, CRISPR-Cas protospacer targets, and phage sensitivity
2020 Nilsen, Miriam Kristine Investigation into the presence of CRISPR-Cas- and R-M systems in Klebsiella pneumoniae and correlation with antibiotic resistance, virulence and plasmids
2020 Bhandari, Ishan Characterization of commensal enterococcal membrane vesicles and their cytotoxic effect on various host cells
2020 Miriam K Nilsen Investigation into the presence of CRISPR-Cas- and R-M systems in Klebsiella pneumoniae and correlation with antibiotic resistance, virulence and plasmids
2018 Wolden, Runa Identifying Staphylococcus haemolyticus surface proteins. Development of a novel method for detection of bacterial surface proteins expressed during colonisation of human keratinocytes
2017 Andreassen, Lotte The population structure of human carriage and clinical isolates of ESBL-producing Escherichia coli and Klebsiella pneumoniae in Norway
2014 Mwansa, Besa James The effect of sub-lethal concentration of ciprofloxacin on the transfer of multidrug resistance plasmids, fitness costs on the host and the stability of the newly acquired plasmids
2014 Reka Thiventhira Kan Staphylococcus aureus proteiner SdrD binde til human Dersmolein 1
2014 Almaz Dori Allelic variation in SdrD among Staphylococcus aureus from healthy carriers and its role in adhesions
2013 Mia E. Hanssen Staphylococcus aureus colonization of human. Study of the interaction between SdrD and Capzβ
2013 Kristine Osther Protein interaction between the Staphylococcus aureus SdrD and human Desmoglein 4
2012 Ramberg, Cathrine Caspersen Molecular characterization of Norwegian clinical isolates of Escherichia coli hyperproducing the chromosomal AmpC beta-lactamase : a regional spread of an IS911-mediated blaAmpC-hyperexpressing ST131 clone
2011 Adou, Koman Mireille Sophie Chinan Study of interaction between BK virus large T-antigen and agnoprotein
2011 Haldorsen, Bjørg Christina Aminoglycoside resistance in clinical Gram-negative isolates from Norway
2011 Lægreid, Kari Jenssen A study of the interaction between MAPKAP Kinase 5 / MK5 and DNAJB1
2011 Ludvigsen, Maria A. The human polyomavirus KI: A study on cell permissivity, sub-cellular localization of VP1 and presence in cerebrospinal fluid and urine

PAST OUTREACH

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